RNA Details
Disease Name
pulmonary arterial hypertension
Tissue
lung
RNA Symbol
CDKN1A
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
ovis aries
Detection Methods
qRT-PCR; LC/MS etc.
Target
NA
Pathway
NA
PubMed ID
Title
Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells
Year
2013
Function
"Inhibition of class I and class II HDACs by apicidin and HDACi VIII suppressed proliferation of newborn PASMC and induced cell cycle arrest in G1 phase. Acetyl H3 levels were higher in newborn PASMC treated with apicidin and HDACi VIII, accompanied by increased expression of p21 and reduced expression of CCND1. Apicidin inhibited serum-induced cell migration, and modulated profiling of expression of genes encoding pro-oxidant and antioxidant enzymes. Contractility and global DNA methylation levels of newborn PASMCs were also markedly modulated by apicidin."
RNA Details
Disease Name
pulmonary arterial hypertension
Tissue
lung
RNA Symbol
CDKN1A
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
ovis aries
Detection Methods
qRT-PCR; LC/MS etc.
Target
NA
Pathway
NA
PubMed ID
Title
Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells
Year
2013
Function
"Inhibition of class I and class II HDACs by apicidin and HDACi VIII suppressed proliferation of newborn PASMC and induced cell cycle arrest in G1 phase. Acetyl H3 levels were higher in newborn PASMC treated with apicidin and HDACi VIII, accompanied by increased expression of p21 and reduced expression of CCND1. Apicidin inhibited serum-induced cell migration, and modulated profiling of expression of genes encoding pro-oxidant and antioxidant enzymes. Contractility and global DNA methylation levels of newborn PASMCs were also markedly modulated by apicidin."